Zilbrysq zilucoplan APPROVED
Drug Profile
ModalityPeptide
RouteSC
Therapy AreaNeurology
Launch2023-10-17
US LOE2036-01-01
Peak Sales Est$1000M
Formulations[{"id":"zilbrysq-sc","doses":"16.6mg (0.416mL), 23mg (0.574mL), 32.4mg (0.810mL)","route":"SC","devi
Companies
UCB (ORIGINATOR)100%
Mechanism: C5 inhibitor
Expert: Humanized monoclonal antibody that binds complement C5, preventing cleavage to C5a and C5b and inhibiting terminal complement-mediated hemolysis and inflammation.
Everyday: Blocks a protein in the immune system that mistakenly attacks the body's own red blood cells.
Targets: ["C5"]
Revenue History
PeriodRevenue ($M)
2024$95M
Q4 2024$35M
Programs (2)
IndicationStageKey StudyRegional Status
Generalized myasthenia gravisAPPROVEDRAISE[{"stage":"APPROVED","region":"US","approval_date":"2023-10-17"},{"stage":"APPRO
IgG4-related diseasePHASE2SELENA[]
Notes
Zilucoplan, a macrocyclic peptide C5 complement inhibitor for generalized myasthenia gravis. Self-administered daily subcutaneous injection; smaller molecule than monoclonal antibodies allows convenient home dosing.
Data from Supabase · Updated 2026-03-24