Plaque Psoriasis
Complete
Full Feynman deep dive: healthy skin biology, disease pathology, IL-23/Th17 cytokine cascade,
drug target mechanisms, prescribing dynamics, trial design, efficacy/safety/convenience comparison,
investment implications. 7 tabs, 5 biology sub-tabs.
Bimzelx / UCB
Skyrizi / ABBV
Tremfya / JNJ
Cosentyx / NOVN
Icotyde / JNJ
Sotyktu / BMY
Oral PCSK9 Inhibitors
Complete
Full Feynman deep dive: cholesterol metabolism, LDL receptor recycling cycle, PCSK9 hijack mechanism,
genetic validation (ARIC), 5 drug modalities (mAb, siRNA, oral peptide, oral small molecule),
CORALreef / PURSUIT / FOURIER / ODYSSEY trial data, competitive positioning, investment scenarios.
6 tabs, 5 biology sub-tabs.
Enlicitide / MRK
AZD0780 / AZN
Repatha / AMGN
Praluent / REGN
Leqvio / NVS
Hidradenitis Suppurativa
Steps 0-5
6 drugs cross-referenced (Bimzelx, Cosentyx, Humira, Rinvoq, Sonelokimab, Remibrutinib).
3 mechanisms (IL-17A/F, IL-17A, TNF). Efficacy table, target landscape, catalyst calendar embedded.
Steps 6-9 not started. HTML dashboard pending.
Bimzelx / UCB
Cosentyx / NVS
Humira / ABBV
Rinvoq / ABBV
CIDP Landscape
In Progress
Exhaustive Vyvgart (ARGX) vs claseprubart (Dianthus) comparison. Response definition differences
(ADHERE triple-criteria vs CAPTIVATE INCAT-only). Four CIDP pathways mapped. IgG subclass analysis.
Not yet stored in tracker. HTML dashboard pending.
Vyvgart / ARGX
Claseprubart / DNTH