Kisunla donanemab APPROVED
Drug Profile
ModalityAntibody
RouteIV
Therapy AreaNeurology
Launch2024-07-02
US LOE2036-07-01
Peak Sales Est$5000M
Formulations[{"id":"kisunla-iv","notes":"Unique stopping rule: discontinue when amyloid cleared on PET","route":
Companies
LLY (ORIGINATOR)100%
Mechanism: Amyloid-beta clearance
Expert: Monoclonal antibody targeting N-terminal pyroglutamate amyloid-beta (N3pG Aβ), promoting clearance of amyloid plaques via microglial phagocytosis.
Everyday: An antibody that clears toxic protein clumps (amyloid plaques) from the brain, potentially slowing Alzheimer's progression.
Targets: ["AMYLOID-BETA"]
Revenue History
PeriodRevenue ($M)
Q3 2024$50M
Programs (1)
IndicationStageKey StudyRegional Status
ADAPPROVEDTRAILBLAZER-ALZ 2[{"stage":"APPROVED","region":"US","label_notes":"Early symptomatic AD with conf
Upcoming Catalysts (1)
Donanemab - Preclinical AD - Ph3 - Interim (TRAILBLAZER-ALZ 3) 2027+
Notes
Unique stop-dosing protocol once plaques cleared
Data from Supabase · Updated 2026-03-24