225Ac-PSMA-617
AAA817
PHASE3
Drug Profile
ModalityRadioligand therapy
RouteIV
Therapy AreaOncology
Peak Sales Est$2000M
Formulations[]
Mechanism: PSMA-targeting
Expert: Ligand targeting prostate-specific membrane antigen (PSMA) conjugated to therapeutic radioisotope (Lu-177 or Ac-225)
Everyday: Targets a protein on prostate cancer cells to deliver radiation directly to tumors
Targets: ["PSMA"]
Programs (1)
Notes
Actinium-225-labeled PSMA-targeted radioligand therapy for metastatic castration-resistant prostate cancer. Alpha-emitting radiopharmaceutical providing more potent DNA damage than beta-emitting Lu-177 PSMA-617 (Pluvicto); for patients progressing after Lu-177.
Data from Supabase · Updated 2026-03-24