XGEVA denosumab APPROVED
Drug Profile
ModalityMonoclonal antibody
RouteSC
Therapy AreaOncology
Launch2010-11-18
Peak Sales Est$2300M
Formulations[{"id":"xgeva-sc","doses":"120mg/1.7mL","route":"SC","setting":"HCP_ADMINISTERED","frequency":"Q4W",
Companies
AMGN (ORIGINATOR)100%
Mechanism: RANK ligand inhibitor
Expert: Fully human IgG2 monoclonal antibody targeting RANK ligand (RANKL). Inhibits osteoclast formation, function, and survival, reducing bone resorption.
Everyday: Blocks a signal (RANKL) that tells bone-eating cells to break down bone. Without this signal, your bones stay stronger and denser — like telling the demolition crew to stop working.
Targets: ["RANKL"]
Revenue History
PeriodRevenue ($M)
2024$2,225M
2025$2,084M
Q4 2024$561M
Q4 2025$447M
Programs (1)
IndicationStageKey StudyRegional Status
Bone metastasesAPPROVEDMultiple pivotals[{"stage":"APPROVED","region":"US","approval_date":"2010-11-18"}]
Notes
BIOSIMILAR RISK: Analysts expect 39% decline in 2026. Already declining -6% in FY2025.
Data from Supabase · Updated 2026-03-24