Raludotatug deruxtecan R-DXd (DS-6000) PHASE2
Drug Profile
ModalityADC
RouteIV
Therapy AreaOncology
Formulations[]
Companies
DSNKY (ORIGINATOR)50%
AZN (CO_DEVELOPER)50%
Mechanism: CDH6-directed (DXd payload)
Expert: First-in-class CDH6-directed ADC with DXd payload. CDH6 overexpression in platinum-resistant ovarian cancer and renal cell carcinoma provides novel therapeutic target.
Everyday: An antibody-drug conjugate that targets CDH6 (Cadherin 6), a protein found on ovarian and kidney cancers.
Targets: ["CDH6"]
Programs (2)
IndicationStageKey StudyRegional Status
PROCPHASE2DS-6000-A-J102[]
RCCPHASE1[]
Upcoming Catalysts (1)
R-DXd - Platinum-Resistant Ovarian - Ph2/3 - Updates (REJOICE-Ovarian01) 2026
Notes
First-in-class CDH6-directed ADC. Phase 2 in platinum-resistant ovarian cancer (46% ORR, 7.9mo PFS). Also in renal cell carcinoma. Earliest stage in the 5DXd portfolio.
Data from Supabase · Updated 2026-03-24