ABBV-RGX-314 ABBV-RGX-314 PHASE3
Drug Profile
ModalityGene therapy
RouteIntravitreal
Therapy AreaOphthalmology
Peak Sales Est$1500M
Formulations[]
Companies
ABBV (ORIGINATOR)100%
Mechanism: AAV gene therapy (anti-VEGF)
Expert: Adeno-associated virus vector delivering anti-VEGF transgene for sustained intraocular expression, reducing need for repeated intravitreal injections.
Everyday: A one-time gene therapy that helps the eye produce its own anti-VEGF protein to treat vision loss.
Targets: ["VEGF"]
Programs (1)
IndicationStageKey StudyRegional Status
wAMDPHASE3ATMOSPHERE[]
Upcoming Catalysts (1)
ABBV-RGX-314 - Wet AMD - Ph3 - Data (ATMOSPHERE) 2026-2027
Notes
AAV gene therapy for wet AMD. Delivers anti-VEGF gene for durable expression. Potential one-time treatment alternative to chronic anti-VEGF injections.
Data from Supabase · Updated 2026-03-24