Yorvipath palopegteriparatide APPROVED
Drug Profile
ModalityTransCon prodrug
RouteSC
Therapy AreaRare Disease
Launch2024-04-30
US LOE2036-01-01
Peak Sales Est$1500M
Formulations[{"id":"yorvipath-sc","doses":"Various strengths","route":"SC","setting":"PATIENT_SELF","frequency":
Companies
ASND (ORIGINATOR)100%
Mechanism: PTH analog
Expert: Long-acting parathyroid hormone prodrug
Everyday: Replaces missing parathyroid hormone
Targets: ["PTH1R"]
Revenue History
PeriodRevenue ($M)
2024$133M
2025$477M
Q4 2025$187M
Programs (1)
IndicationStageKey StudyRegional Status
HypoparathyroidismAPPROVEDPaTHway[{"stage":"APPROVED","region":"US","approval_date":"2024-10-18"}]
Clinical Studies (1)
PaTHway PHASE3
COMPLETED · n=82
Primary EP: [{"name":"Independence from IV calcium and active vitamin D at Week 26","type":"responder","results":[{"value":79,"arm_name":"TransCon PTH"},{"value":5,"arm_name":"Placebo"}]}]
Efficacy: Met primary: 79% vs 5% achieved independence from IV calcium and active vitamin D (p<0.0001). Published in peer-reviewed journal.
Notes
FDA approved Aug 12, 2024. First-ever hypoparathyroidism treatment. 2025 revenue €477M (preliminary). Q4 2025 alone was €187M. Transformational launch.
Data from Supabase · Updated 2026-03-24