Expert: Antisense oligonucleotide (ASO) targeting hepatic prekallikrein (KLKB1) mRNA. Reduces plasma prekallikrein levels, thereby decreasing kallikrein-mediated bradykinin generation — the primary driver of angioedema attacks in HAE.
Everyday: A designer strand of genetic code that silences the gene making prekallikrein — a protein that triggers the swelling cascade in hereditary angioedema. Without prekallikrein, the dangerous swelling attacks cannot start.
Targets: []